“Our physician recommended ADVATE because it contains no blood-based additives.”

Yudith Menifee, CA
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Assurance Eliminates Potential Risk Of Viral Transmission

ADVATE eliminates the potential risk of viruses that may be carried by blood-based additives because no plasma proteins are added at any stage of processing.2-4,a

There have been no confirmed reports of viral transmission with recombinant factor VIII therapies.

The Medical and Scientific Advisory Council (MASAC) of the National Hemophilia Foundation recommends that increased efforts should be made to eliminate human and bovine proteins from the processing of recombinant products.2

Baxter was there for the hemophilia community with the introduction of the first factor VIII therapy free of blood-based additives: ADVATE. 3,4,10

Important Risk Information for ADVATE

You should not use ADVATE if you are allergic to mouse or hamster proteins or any ingredients in ADVATE.

You could have an allergic reaction to ADVATE. Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, light-headed, dizziness, nausea, or fainting.

Your body may form inhibitors to Factor VIII, which may stop FVIII products including ADVATE from working properly. Contact your doctor if you are not able to prevent or control bleeding episodes with your regular doses of Factor VIII therapy.

Indication for ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method]

ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method] is a medicine used to replace clotting factor VIII that is missing in people with hemophilia A (also called “classic” hemophilia). ADVATE is used to prevent and control bleeding in adults and children (0-16 years) with hemophilia A. Your healthcare provider may give you ADVATE when you have surgery. ADVATE can reduce the number of bleeding episodes in adults and children (0-16 years) when used regularly (prophylaxis).

ADVATE is not used to treat von Willebrand Disease.

Detailed Important Risk Information for ADVATE

You should not use ADVATE if you are allergic to mice or hamsters or any ingredients in ADVATE.

You should tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines and dietary supplements, have any allergies, including allergies to mice or hamsters, are nursing, are pregnant, or have been told that you have inhibitors to factor VIII.

You can have an allergic reaction to ADVATE. Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea, or fainting.

Your body may form inhibitors to factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.

Side effects that have been reported with ADVATE include: cough, sore throat, unusual taste, abdominal pain, diarrhea, nausea/vomiting, headache, fever, dizziness, hot flashes, chills, sweating, joint swelling/aching, itching, hematoma, swelling of legs, runny nose/congestion, and rash.

Call your healthcare provider right away about any side effects that bother you or if your bleeding does not stop after taking ADVATE.

Please see ADVATE full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.