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Detailed Important Risk Information
and Full Prescribing Information (PI)

• Fit for You
  • Flexibility
  • Single-Vial Dosing
  • Mixing
  • Single Vial Dose Finder
• Safety & Efficacy
  • Efficacy
  • Safety
  • Prophylaxis
  • Significant Real-World Experience
  • Extensive Clinical Trials
• Assurance
  • Eliminates Potential Risk of Viral Transmission
  • Evolution of Factor VIII Processing
• Community Stories
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• Trial Program
• FAQs

Community StoriesIsaiah S. in Hoboken, NJ

I'm 11 years old and want to tell you that living with hemophilia is okay. There are terrific things and bad things about it. One bad thing is you have to be very careful when you play sports, because you could really hurt yourself. Right now, I play baseball, so I can't play another sport right after the baseball season is over because my joints need to take a little break.

The good thing is even though you have hemophilia you still have doctors, nurses, and other people that support you. I go to St. Michael's Medical Center in Newark, NJ, and they are super cool there. Every year around Christmas we have a nice party. We dance and get balloon art and presents. Lucky for me, my birthday is in late December. I get Christmas presents from the hospital, my parents, and then my birthday presents come. But it's not the presents that matter. What matters is you have people who love you and care for you. I've been very lucky to have such great people working with me. When I go there, they treat me really nice. My doctor likes to say a lot of funny jokes. At least HE thinks they're funny!

I was glad when my mom decided to switch me to ADVATE. It doesn't take many vials to infuse when I need my factor.⁴

I'm happy to say I've never had any major problems due to my hemophilia. And I'm lucky to be surrounded by the best team for me.

Isaiah S. Hoboken, NJ

Not all activities are appropriate for all people. Consult with your physician or healthcare professional to determine which activities are appropriate for you and what safety precautions to take when participating in a particular sport or exercise regimen.

ADVATE [Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method] is a medicine used to replace clotting factor VIII that is missing in people with hemophilia A (also called “classic” hemophilia). ADVATE is used to prevent and control bleeding in people with hemophilia A. Your healthcare provider may give you ADVATE when you have surgery.

ADVATE is not used to treat von Willebrand Disease.

Detailed Important Risk Information for ADVATE

You should not use ADVATE if you are allergic to mice or hamsters or any ingredients in ADVATE.

You should tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines and dietary supplements, have any allergies, including allergies to mice or hamsters, are nursing, are pregnant, or have been told that you have inhibitors to factor VIII.

You can have an allergic reaction to ADVATE. Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea, or fainting.

Your body may form inhibitors to factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.

Side effects that have been reported with ADVATE include: cough, sore throat, unusual taste, abdominal pain, diarrhea, nausea/vomiting, headache, fever, dizziness, hot flashes, chills, sweating, joint swelling/aching, itching, hematoma, swelling of legs, runny nose/congestion, and rash.

Call your healthcare provider right away about any side effects that bother you or if your bleeding does not stop after taking ADVATE.

Please see ADVATE full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.