What is ADVATE?
ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in people with hemophilia A (also called “classic” hemophilia). ADVATE is used to prevent and control bleeding in adults and children (0-16 years) with hemophilia A. Your healthcare provider (HCP) may give you ADVATE when you have surgery. ADVATE can reduce the number of bleeding episodes in adults and children (0-16 years) when used regularly (prophylaxis). ADVATE is not used to treat von Willebrand disease.1
Unexpected bleeds happen
Be ready for them with proven on-demand bleed control. Access to an effective, on-demand treatment for breakthrough bleeds is important for people living with hemophilia A. ADVATE has been shown to control bleeding episodes in children and adults.1
study design1
ADVATE on-demand use was studied in a clinical trial of 111 people 10 years or older with moderate to severe hemophilia A. Subjects took ADVATE on-demand to treat a total of 510 bleeding episodes in addition to their regular prophylaxis treatment. Investigators rated the quality of the on-demand treatment response using a scale of excellent, good, fair, or none.
bleed control data
In a study of 111 patients, ADVATE on-demand controlled bleeds and was rated positively by patients1
were controlled with 1 or 2
infusions1
were rated as excellent
or good1
In on-demand use, what is an excellent or good rating?
In these ADVATE clinical studies, an excellent rating means there was abrupt pain relief and/or clear improvement in symptoms within approximately 8 hours after 1 infusion. A good rating means there was definite pain relief and/or improvement in symptoms within approximately 8 hours after an infusion, but possibly requiring more than 1 infusion.2
study design1
ADVATE on-demand use was studied in a clinical trial of 111 people 10 years or older with moderate to severe hemophilia A. Subjects took ADVATE on-demand to treat a total of 510 bleeding episodes in addition to their regular prophylaxis treatment. Investigators rated the quality of the on-demand treatment response using a scale of excellent, good, fair, or none.
Selected Important Risk Information
What else should I know about ADVATE and Hemophilia A?
Your body may form inhibitors to factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop ADVATE from working properly. Talk with your HCP to make sure you are carefully monitored with blood tests for the development of inhibitors to factor VIII.
Please see Detailed Important Risk Information below.
Helpful resources
![ADVATE® [Antihemophilic Factor (Recombinant)] - Bleed Assessment worksheet](/dist/images/guide/worksheet-img.webp)
Goals worksheet
This worksheet can help you track your ABR progress and start your journey striving toward zero bleeds.
![ADVATE® [Antihemophilic Factor (Recombinant)] - Doctor discussion guide](/dist/images/guide/guide-img.webp)
Doctor discussion guide
Have more productive conversations with your healthcare provider about your treatment.
