ADVATE is a medicine used to prevent and control bleeding in adults and children with hemophilia A. ADVATE is not used to treat von Willebrand disease.
ADVATE Has Health-Related Quality-of-Life Results
After 12 months of prophylaxis treatment for bleeding episodes with ADVATE, people with hemophilia A rated improvements in select health-related quality-of-life measures compared with on-demand treatment.1-3
Improvements observed in 2 areas:
Bodily pain
Reduced levels of pain and
improvements in the limitations of
work due to pain.1,2
Role physical
Improvements in the ability to
perform work or other daily
activities.1,2
Changes were not seen in:
Physical
functioning
Changes not observed in limitations
to a range of minor and major
physical activities.1,2
General health
Changes not observed in the views
and expectations of overall
health.1,2
Clinically meaningful changes were not seen in the mental health-related component score and subcategories of Mental Health, Role Emotional, Social Functioning, and Vitality.1
Categories with clinically meaningful improvements1-3
Bodily pain
The amount of pain experienced by a patient and how much pain interferes with normal work.
Role physical
The impact physical health can have on performing work or other daily activities.
Categories without clinically meaningful changes1-3
Physical health
The physical health-related subcategories of General Health and Physical Functioning.
Mental health
The mental health-related component score and subcategories of Mental Health, Role Emotional, Social Functioning, and Vitality.
Flexible dosing
options
Explore ADVATE
safety information
References
- ADVATE Prescribing Information.
- Maruish ME, ed. User’s Manual for the SF-36v2 Health Survey. 3rd ed. Lincoln, RI: QualityMetric Incorporated; 2011.
- Valentino LA, Mamonov V, Hellmann A, et al. A randomized comparison of two prophylaxis regimens and a paired comparison of on-demand and prophylaxis treatments in hemophilia A management [published correction appears in J Thromb Haemost. 2012;10(6):1204]. J Thromb Haemost. 2012;10(3):359-367.
Selected Important Risk Information
Do not use ADVATE if you are allergic to mice or hamsters or are allergic to any ingredients in ADVATE. Tell your HCP if you are pregnant or breastfeeding because ADVATE may not be right for you.
