Only ADVATE has 15+ years of experience in the real world as a latest-generation plasma/albumin-free recombinant VIII3,10
Evidence spanning over 15 years from 15 prospective studies4-6,9,11,12
More than 33 billion International Units (IUs) distributed worldwide13*
*Based on units sold, as of February 2019.
Proven clinical performances4-6,9,11,12
Third generation full-length molecule, similar to the factor VIII that occurs naturally in the body3,10
1st genetically manufactured factor VIII.13
Ushers in the era of recombinant factor VIII treatment.
Recombinant, with plasma-derived proteins in culture medium, but not in final formulation.
The amount of blood components used in processing was reduced, although some still remain.
Specifically, plasma proteins are still used in the cell-growth phase.10,15
First needleless transfer device: BAXJECT®.13
First recombinant factor VIII free of blood-based additives, introducing the latest generation of treatment: ADVATE.10
Recombinant, with no plasma-derived proteins in culture medium or final formulation.
In 2003, ADVATE was introduced as the first recombinant factor VIII treatment to be free of blood-based additives. No plasma proteins are added at any stage of processing.3,15,16
There were no confirmed reports of viral transmission with recombinant factor VIII treatments.
The redesigned BAXJECT II device allowed mixing in less than 1 minute and included built-in filters to maintain product purity.13
First factor VIII 3000 IU single-vial dose.13
First & only recombinant factor VIII 1700 IU single-vial dose.13
First & only recombinant factor VIII with physical health-related quality of life results in the prescribing information.3
First factor VIII 4000 IU single-vial dose.3
First & only factor VIII 2 mL diluent option (250, 375, 500, 750, 1000, 1500, and 1700 IU).3,13
ADVATE is a medicine used to replace clotting factor (factor VIII or antihemophilic factor) that is missing in
Do not use ADVATE if you:
ADVATE is not used to treat von Willebrand disease.
Do not use ADVATE if you:
Tell your HCP if you are pregnant or breastfeeding because ADVATE may not be right for you.
Tell your HCP if you:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For additional safety information, click here for Prescribing Information and discuss with your HCP.
myPKFiT for Patients Mobile Application is Rx only. For safe and proper use of the myPKFiT Mobile App, please refer to the complete instructions for use in the User Manual.